RNA Details
Disease Name
heart failure
Tissue
heart
RNA Symbol
mir-18a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
PCR; immunofluorescence etc.
Target
CTGF;TSP-1
Pathway
NA
PubMed ID
Title
MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure
Year
2011
Function
"Our data support a role for cardiomyocyte-derived miR-18 during cardiac aging, in the fine-tuning of cardiac extracellular matrix protein levels. During aging, decreased miR-18 and increased CTGF and TSP-2 levels identify the failure-prone heart."